Rabbit model of subchondral bone bruise and the treatment potential of calcitonin.
نویسندگان
چکیده
BACKGROUND This study characterized a novel rabbit model of subchondral bone bruise and investigated the intervening effect of calcitonin. METHODS Bone bruise was implemented via controlled free-fall counterpoise on the medial tibial subchondral bone of 5-month-old New Zealand rabbits, with 3, 2.5, or 2 Joules of energy. Subsequent subchondral bone bruise was characterized via magnetic resonance imaging, micro computed tomography, and histology. Calcitonin was administered for 3 weeks, and the changes in subchondral bone were characterized. RESULTS The severity of subchondral bone bruise lesions correlated with the energy applied. The lesions involved trabecular separation and reduced trabecular number, with bone marrow edema and trabecular micro-fracture. With calcitonin treatment, subchondral bone marrow edema subsided and trabecular ultrastructure repaired. CONCLUSION Free fall counterpoise is a promising method to establish a subchondral bone bruise model in rabbits. Calcitonin injection is a potential treatment for subchondral bone bruise lesions.
منابع مشابه
Treatment of Osteopenic Menopause Women as a Public Health Problem with Nasal Calcitonin; an Original Study on Follow up Markers
Introduction: Various therapeutic options such as Calcitonin are suggested for patients with low bone density. However, the efficacy remains uncertain in all patients. C-telopeptide of type I collagen (CTx) is the authentic bone marker which is recently used to assess the bone turnover. This study aimed at revealing the therapeutic effects of Calcitonin on osteopenic women via ...
متن کاملSubchondral Insufficiency Fracture of the Femoral Head Treated with Core Decompression and Bone Void Filler Support
Subchondral insufficiency fracture of the femoral head (SIFFH) is characterized by acute onset hip pain without overt trauma. It appears as a low intensity band with bone marrow edema on T1-weighted MRI. The most common course of treatment is protected weight bearing for a period of several weeks. Total hip arthroplasty (THA) has been commonly used if the patient does not respond to the initial...
متن کاملMicroinjection of calcitonin in midbrain periaqueductal gray attenuates hyperalgesia in a chronic constriction injury rat model
Objective(s): As heat, pain is one of the most common clinical symptoms. Generally, calcitonin (CT) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. However, the detailed mechanism remains unknown.Materials and Methods: In this study, chronic constriction injury (CCI) rat model was created, and ho...
متن کاملThe effect of bone-bruise lesions on pain in patients with traumatic knee injury.
Traumatic knee injuries affect numerous physically active individuals each year. Damage to subchondral bone, often termed bone bruise, is frequently detected on magnetic resonance imaging (MRI) during the diagnosis of traumatic knee injury. Little is known regarding the effects of bone bruises on pain in individuals with traumatic knee injury. Understanding the presentation of self-reported pai...
متن کاملRationale for the potential use of calcitonin in osteoarthritis.
This review provides evidence that osteoarthritis (OA) or a major subset of OA is not only a disease of cartilage but also a disorder of subchondral bone. This review also discusses the potential efficacy of a bone and cartilage active agent, calcitonin, and discusses how calcitonin might be useful in the pharmaceutical treatment of OA.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- American journal of translational research
دوره 9 12 شماره
صفحات -
تاریخ انتشار 2017